I have 2 questions. Interesting question. I'll take a stab, if anyone finds something wrong, feel free to correct me.
Radon, though radioactive, is a noble gas. Which means it's chemically inert. It doesn't really interact with anything, although it sticks to charcoal for some reason because apparently everything sticks to charcoal (I'd love for someone to explain that bit to me). The only real leakage you would be concerned with is not having an airtight system where air, including radon, would get pushed/pulled into the house. I assume PVC is non-porous so that you won't have any emanation through the piping material, so as far as I know, so long as you have an airtight system, nothing is going to "leak" into the house.
But since you got me thinking about it, I wonder how much of the radioactive decay products, which are "sticky," end up sticking to the inside of the PVC pipe. I wonder, if you've had a system that's been active for a number of years, or if you have active systems that are mitigating houses with extraordinary radon sources, how much of the decay products are deposited throughout the system. Maybe you would be able to detect gamma coming through the system piping/fan housing? Hmm. Just thinking out loud here.